中文名称(Chinese name):2′-脱氧尿苷-5′-单磷酸二钠
中文别名(Chinese aliases): 2′-脱氧尿苷三磷酸二钠盐
英文名称(English name):2'-Deoxyuridine 5'-monophosphate disodium salt
英文别名(English aliases):Disodium 2'-deoxy-5'-O-phosphonatouridine
CAS No 42155-08-8
分子式(Molecular formula):C9H14N2NaO8P
分子量(Molecular weight):338.18
分子结构(structural formula):

物化性质(Physical properties):
本品为白色或米白色固体粉末,易溶于水
This product is a white or off white solid powder, easily soluble in water
纯度(Purity)HPLC:≥99.0%
含量(Contents)dry basis:≥98.0%
贮藏(storage):-20℃保存。Store at -20 ℃.
应用领域(Application field):
1.DNA合成研究 :dUMP 是胸苷酸合成酶(TS)催化反应的直接底物,研究其代谢可以揭示 DNA 合成调控机制。
2.抗癌药物开发: dUMP 是抗癌药物(如 5-氟尿嘧啶,5-FU)的靶标之一。5-FU 是一种嘧啶类似物,其代谢物会与 dUMP 竞争胸苷酸合成酶,从而抑制 DNA 合成,导 致癌细胞死亡。
3.酶学实验与蛋白质功能分析: dUMP 是胸苷酸合成酶、脱氧核苷酸激酶等酶的研究底物,可用于研究这些酶的功能、活性和结构。
参考文献:
[1] Longley, D. B., Harkin, D. P., & Johnston, P. G. (2003). “5-Fluorouracil: Mechanisms of action and clinical strategies.” Nature Reviews Cancer, 3(5), 330–338.
[2] Jones, M. E. (1980). “Pyrimidine nucleotide biosynthesis in animals: Genes, enzymes, and regulation of UMP biosynthesis.” Annual Review of Biochemistry, 49(1), 253–279.
[3] Nielsen, J., & Keasling, J. D. (2016). “Engineering cellular metabolism.” Cell, 164(6), 1185–1197.
[4] Carreras, C. W., & Santi, D. V. (1995). “The catalytic mechanism and structure of thymidylate synthase.” Annual Review of Biochemistry, 64(1), 721–762.