中文名称(Chinese name):烟酰胺腺嘌呤二核苷酸
中文别名(Chinese aliases):β-烟酰胺腺嘌呤双核苷酸
英文名称(English name):β-Nicotinamide adenine dinucleotide
英文别名(English aliases):NAD
CAS No.53-84-9
分子式(Molecular formula):C21H27N7O14 P2
分子量(Molecular weight):663.43
分子结构(structural formula):

物化性质(Physical properties):
本品为白色或类白色粉末。
This product is a white to off-white powder.
纯度(Purity)HPLC:≥98.0%
贮藏(storage):密封,冷冻保存。Preserve in tight containers, in a freezing place.
应用领域(Application field)
1. 能量代谢
NAD⁺ 在细胞的能量代谢中扮演着至关重要的角色,特别是在糖酵解、三羧酸循环(TCA循环)和氧化磷酸化过程中。
2. DNA修复与衰老
NAD⁺ 是聚腺苷二磷酸核糖聚合酶 (PARP) 的底物,这是一种参与DNA修复的酶。
3. Sirtuins与基因表达调控
NAD⁺ 是 Sirtuins 家族酶(依赖NAD⁺的去乙酰化酶)的必需辅酶,Sirtuins 参与调控基因表达、代谢过程、抗氧化反应和衰老。
4. 免疫系统和炎症反应
NAD⁺ 还参与调节免疫系统的功能和炎症反应。
5. 神经系统功能
NAD⁺ 在神经元功能和脑健康中也起到重要作用。
参考文献:
[1] Lehninger, A. L., Nelson, D. L., & Cox, M. M. (2008). Lehninger Principles of Biochemistry (5th ed.). W.H. Freeman.
[2] Houtkooper, R. H., & Auwerx, J. (2012). Exploring the therapeutic space around NAD⁺. Journal of Cell Biology, 199(2), 205-207.
[3] Belenky, P., Bogan, K. L., & Brenner, C. (2007). NAD⁺ metabolism in health and disease. Trends in Biochemical Sciences, 32(1), 12-19.
[4] Imai, S., & Guarente, L. (2014). NAD⁺ and sirtuins in aging and disease. Trends in Cell Biology, 24(8), 464-471.
[5] Haigis, M. C., & Sinclair, D. A. (2010). Mammalian sirtuins: biological insights and disease relevance. Annual Review of Pathology: Mechanisms of Disease, 5(1), 253-295.
[6] Verdin, E. (2015). NAD⁺ in aging, metabolism, and neurodegeneration. Science, 350(6265), 1208-1213.
[7] Chini, E. N., et al. (2020). The NADase CD38 is a key regulator of NAD⁺ homeostasis in metabolic aging. Nature Metabolism, 2(7), 291-300.
[8] Mills, K. F., et al. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabolism, 24(6), 795-806.
[9] Fang, E. F., et al. (2016). NAD⁺ rejuvenates aged gut adult stem cells. Aging Cell, 15(4), 524-536.
[10] Verdin, E., et al. (2020). NAD⁺ boosting in neurodegenerative disorders: The sirtuin pathway. Cell Research, 30(8), 609-610.