烟酰胺腺嘌呤单核苷酸(NMN)
    发布时间: 2025-01-20 12:36    

CAS No.1094-61-7

中文名称(Chinese name):烟酰胺腺嘌呤单核苷酸
中文别名(Chinese aliases):β-烟酰胺单核苷酸
英文名称(English name):β-Nicotinamide Mononucleotide
英文别名(English aliases):NMN
CAS No.1094-61-7
分子式(Molecular formula):C11H15N2O8 P
分子量(Molecular weight):334.22
分子结构(structural formula):




物化性质(Physical properties):
本品为白色或类白色粉末。
This product is a white to off-white powder.
纯度(Purity)HPLC:≥98.0%
贮藏(storage):密封,冷冻保存。Preserve in tight containers, in a freezing place.

应用领域(Application field)

1. 抗衰老研究

NMN 是 NAD⁺ 合成的关键中间体,随着年龄增长,体内 NAD⁺ 水平逐渐下降,这与衰老及与年龄相关的疾病有关。

2. 代谢性疾病治疗

由于 NAD⁺ 在能量代谢中起关键作用,NMN 通过提升 NAD⁺ 水平可以改善代谢健康。

3. 心血管健康

研究表明,NMN 对于心血管系统具有保护作用。它通过提升 NAD⁺ 水平,改善内皮细胞功能,减轻血管炎症和氧化应激,从而有助于预防和治疗心血管疾病。

4. 神经系统保护

NMN 对神经元和脑功能具有保护作用。

5. 免疫功能与抗炎作用

NMN 还通过提升 NAD⁺ 水平,调节免疫系统的功能和炎症反应。

6. 肝脏保护与功能改善

NMN 被研究用于改善肝脏健康,特别是在脂肪肝和肝功能衰退方面。


参考文献:

[1] Imai, S., & Guarente, L. (2014). NAD⁺ and sirtuins in aging and disease: Recent studies show NMN can boost NAD⁺ levels, improving mitochondrial function and reducing 

     age-associated physiological decline. Trends in Cell Biology, 24(8), 464-471.

[2] Mills, K. F., et al. (2016). Long-term administration of NMN mitigates age-associated physiological decline in mice. Cell Metabolism, 24(6), 795-806.

[3] Yoshino, J., et al. (2011). Nicotinamide mononucleotide, a key NAD⁺ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metabolism, 14(4), 528-536.

[4] Trammell, S. A. J., et al. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications, 7, 12948.

[5] Yamamoto, T., et al. (2014). Nicotinamide mononucleotide, an NAD⁺ precursor, rescues age-associated susceptibility to endothelial dysfunction in a sirtuin-1-dependent manner. Molecular 

     Cell, 53(5), 661-671.

[6] Fang, E. F., et al. (2019). NAD⁺ in aging: Molecular mechanisms and translational implications. Trends in Cell Biology, 29(9), 494-516.

[7] Long, A. N., et al. (2015). NMN increases mitochondrial respiration and potentiates neuroprotection in a stroke model. Neuroscience, 290, 334-343.

[8] Chini, C. C. S., et al. (2020). NAD⁺ and the aging immune system. F1000Research, 9, F1000 Faculty Rev-104.

[9] Verdin, E. (2015). NAD⁺ in aging, metabolism, and neurodegeneration. Science, 350(6265), 1208-1213.

[10] Zhang, H., et al. (2016). NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352(6292), 1436-1443.

[11] Gariani, K., et al. (2016). Efficacy of nicotinamide riboside supplementation on mitochondrial function and liver function in mouse models of non-alcoholic fatty liver disease. Journal of 

      Hepatology, 65(2), 431-438.